Beneficial effects of WON-21 on the symptoms of a hangover and identification of active compounds: experimental studies on antioxidant, anti-inflammation, and alcohol-metabolizing enzymes

Abstract Many hangover cure products containing natural ingredients that are also effective against alcohol-related liver damage or improve function have recently become available. In addition to curing damage, antioxidants, anti-inflammatory agents, and blood ethanol reduction aids emerging as relief targets reduce symptoms. We investigated the ameliorating effect of WON-21 herbal medicinal by studying mixing ratio oriental medicine concept with respect antioxidant potential, anti-inflammation, aldehyde dehydrogenase (ALDH) alcohol (ADH) enzyme activities. its components exerted effects. Rutin, taxifolin, quercetin showed superior effects compared other components. WON-12 effectively reduced iNOS COX-2 in LPS-stimulated macrophages. Quercetin apigenin were 2 compounds for inhibition COX-2. significantly increased activities ALDH ADH enzymes a concentration-dependent manner.